Past Clinical Trials
Below is a (partial) collection of previous clinical trials for PSC. These trials have either been successfully completed or withdrawn before completion.
While the discontinuation of trials can often be disheartening, these trials still provide valuable information for us to better understand how to develop a safe and effective treatment for PSC. We are incredibly grateful for all current and past participants in clinical trials; your contributions are invaluable to the development of an effective treatment for PSC, and to the PSC community as a whole.
For a full list of studies that have been conducted using de-identified patient data, as well as other special projects undertaken in collaboration with the PSC Partners Patient Registry, please visit the Registry Impact page.
Past PSC Clinical Trials
♦ Indicates Studies Conducted with PSC Partners Collaboration or Input
Sponsor or Research Institution
Study Title & Phase
Details (updated 2/2024)
Links
Gilead Sciences
♦
Safety, Tolerability, and Efficacy of Cilofexor in Non-Cirrhotic Adults With Primary Sclerosing Cholangitis (PRIMIS)
Phase 3 Study
Discontinued September 26, 2022: Original estimated study completion date: August 2025.
Statement from Gilead Sciences about the study discontinuation can be found at the Learn More link to the right.
ClinicalTrials.gov Identifier: NCT03890120
Pliant Therapeutics
♦
Phase 2a Evaluation of Safety, Tolerability, and Pharmacokinetics of PLN-74809 in Patients With Primary Sclerosing Cholangitis (PSC)
Phase 2a Study
Completed March 18, 2024: Adult PSC patients. 50 Study locations in Australia, Canada, Europe, UK, and US.
The Registry will continue to update this trial with more information as it becomes available.
ClinicalTrials.gov Identifier: NCT04480840
ClinicalTrials.gov Website
ClinicalTrials.gov is a website that records clinical trials being conducted around the world. This website is maintained by the National Library of Medicine (NLM) at the US National Institutes of Health (NIH).
Click the link below for a full list of all previous clinical trials for PSC.